Effect of high-fat diet on cognitive impairment in triple-transgenic mice model of Alzheimer's disease

SK Sah, C Lee, JH Jang, GH Park - Biochemical and biophysical research …, 2017 - Elsevier
… β-amyloid (Aβ) peptide and hyperphosphorylated protein tau … underlying memory impairment
in young AD transgenic micemice (non-Tg) and triple transgenic AD (3xTg-AD) mice aged …

[HTML][HTML] Contributions of a high-fat diet to Alzheimer's disease-related decline: a longitudinal behavioural and structural neuroimaging study in mouse models

CPE Rollins, D Gallino, V Kong, G Ayranci… - NeuroImage: Clinical, 2019 - Elsevier
… Adolescent high-fat diet-induced obesity altered adult brain … the brain morphology of the
triple transgenic mouse model of AD (… is that high-fat feeding induced memory deficits and brain …

[HTML][HTML] Tetrahydrobiopterin improves recognition memory in the triple-transgenic mouse model of Alzheimer's disease, without altering amyloid-β and tau pathologies

H Fanet, M Tournissac, M Leclerc… - … of Alzheimer's …, 2021 - content.iospress.com
… could ameliorate memory impairment in 3xTg-AD mice owing to … were fed from the age of 6
months a control (CD) or a high-fat diet … independently of an aggravation of amyloid-β or tau

[PDF][PDF] Exercise Attenuates High-Fat Dietinduced Disease Progression in 3xTg-AD Mice

D Kim, J Cho, I Lee, Y Jin, H Kang - Medicine & Science in Sports …, 2017 - researchgate.net
… cognitive impairments in the tripletransgenic AD (3xTg-AD) mice. … alleviated AA and tau
pathology and synaptic instability in … High-fat diet-induced memory impairment in triple transgenic

[HTML][HTML] The effect of dietary fat consumption on Alzheimer's disease pathogenesis in mouse models

A Amelianchik, L Sweetland-Martin… - Translational Psychiatry, 2022 - nature.com
diet-induced obesity affects AD-related phenotypes in mice. … -fed 3xTgAD mice no longer
showed memory impairment … and increased tau pathology in a triple transgenic mouse model of …

High-fat diet negatively affects brain markers, cognitive behaviors, and noncognitive behaviors in the rTg4510 tau mouse model

SLP Lippi, RE Barkey, MN Rodriguez - Physiology & Behavior, 2023 - Elsevier
… in those with not only mild cognitive impairment (MCI), but also … 3xTg-AD mouse model of
AD (containing amyloid plaques, … a high-fat diet could exacerbate tau pathology and behavioral …

[HTML][HTML] High-fat diet exacerbates cognitive decline in mouse models of Alzheimer's disease and mixed dementia in a sex-dependent manner

OJ Gannon, LS Robison, AE Salinero… - Journal of …, 2022 - Springer
… models of both AD and MxD, we found that diet-induced … -like memory deficits were observed
in AD and MxD mice of … testosterone) increases Aβ and tau pathology but is rescued by …

[PDF][PDF] HighFat Diet Modulates Hepatic Amyloid β and Cerebrosterol Metabolism in the Triple Transgenic Mouse Model of Alzheimer's Disease

CR Bosoi, M Vandal, M Tournissac… - Hepatology …, 2021 - Wiley Online Library
… We show that the AD triple transgenic mouse model (3xTg-AD… same or similar tests
probing for memory loss is an essential … in diet-induced obese mice. Diabetologia 2016;59:592-603. …

High fat diet treatment impairs hippocampal long-term potentiation without alterations of the core neuropathological features of Alzheimer disease

IH Salas, A Weerasekera, T Ahmed… - … of disease, 2018 - Elsevier
… , littermate mice were separated into two independent groups … high fat diet induced
phosphorylation of Tau at disease-linked … memory impairments associated with the long-term high

A high fat/cholesterol diet recapitulates some Alzheimer's disease-like features in mice: focus on hippocampal mitochondrial dysfunction

G Mancini, C Dias, CF Lourenco… - … of Alzheimer's …, 2021 - content.iospress.com
… cognitive impairment in 3xTgAD mice, it induced an impairment … the triple transgenic mouse
model of Alzheimer’s disease (… , memory impairment was not associated with changes in Aβ …